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miR-10 in development and cancer Lund AHCell Death Differ 2010[Feb]; 17 (2): 209-14The microRNA (miRNA) miR-10 family has attracted attention because of its conservation and the position of the miR-10 genes within the Hox clusters of developmental regulators. In several species, miR-10 is coexpressed with a set of Hox genes and has been found to regulate the translation of Hox transcripts. In addition, members of the miR-10 family are de-regulated in several cancer forms. Aside from acting in translational repression, miR-10 was recently found to bind a group of transcripts containing a terminal oligo-pyrimidine (TOP) motif and to induce their translation, thereby adding a new function to the miRNA repertoire.|*Gene Expression Regulation, Developmental[MESH]|*Gene Expression Regulation, Neoplastic[MESH]|Animals[MESH]|Genes, Homeobox/physiology[MESH]|Humans[MESH]|MicroRNAs/*physiology[MESH]|Neoplasms/*genetics[MESH]|Protein Biosynthesis/genetics[MESH] |
