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English Wikipedia
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Population biology of the human restricted pathogen, Streptococcus pyogenes Bessen DEInfect Genet Evol 2009[Jul]; 9 (4): 581-93Streptococcus pyogenes, also referred to as beta-hemolytic group A streptococci, are strictly human pathogens with a global distribution and high prevalence of infection. The organisms are characterized by high levels of genetic recombination, extensive strain diversity, and a narrow habitat. This review highlights many key features of the population genetics and molecular epidemiology of this biologically diverse bacterial species, with special emphasis on ecological subdivisions and tissue-specific infections, strain diversity and population dynamics in communities, selection pressures arising from the specific host immune response and antibiotic exposure, and within-host selection during the course of invasive disease.|*Evolution, Molecular[MESH]|Anti-Bacterial Agents/pharmacology[MESH]|Drug Resistance, Bacterial[MESH]|Ecology[MESH]|Genetics, Population[MESH]|Humans[MESH]|Molecular Epidemiology[MESH]|Phylogeny[MESH]|Selection, Genetic[MESH]|Streptococcal Infections/classification/epidemiology/*microbiology[MESH]|Streptococcus pyogenes/classification/drug effects/*genetics/pathogenicity[MESH] |
