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lüll Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding Noble W; Garwood CJ; Hanger DPPrion 2009[Apr]; 3 (2): 78-83Many neurodegenerative disorders share common features including the accumulation of aggregated misfolded proteins, neuroinflammation and the induction of apoptosis. While the contributions of each of these individual elements to neuronal death remain unclear, a commonly used antibiotic, minocycline, has been shown to reduce the progression and severity of disease in several models of neurodegeneration by variously downregulating these molecular pathways. Here we discuss the evidence for the potential of minocycline as a broad-specificity therapeutic agent for those neurodegenerative diseases that are characterized by the presence of misfolded proteins.|Animals[MESH]|Anti-Bacterial Agents/chemistry/*therapeutic use[MESH]|Humans[MESH]|Minocycline/chemistry/*therapeutic use[MESH]|Molecular Structure[MESH]|Neurodegenerative Diseases/*drug therapy/*metabolism[MESH]|Protein Folding[MESH] |