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lüll The amyloid hypothesis for Alzheimer s disease: a critical reappraisal Hardy JJ Neurochem 2009[Aug]; 110 (4): 1129-34The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer's disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review the current status of the hypothesis and suggest that a major scientific need is to understand the normal function of amyloid-beta precursor protein (APP) and think how this may relate to the cell death in the disease process.|Alzheimer Disease/*drug therapy/*etiology/metabolism[MESH]|Alzheimer Vaccines/adverse effects[MESH]|Amyloid beta-Peptides/antagonists & inhibitors/immunology/*metabolism[MESH]|Amyloid beta-Protein Precursor/*metabolism[MESH]|Brain/*drug effects/metabolism/*physiopathology[MESH]|Cerebral Arteries/drug effects/metabolism/physiopathology[MESH]|Clinical Trials as Topic/methods/standards[MESH]|Disease Progression[MESH]|Humans[MESH]|Nerve Degeneration/drug therapy/metabolism/physiopathology[MESH] |