free     free     free  :  Publisher English Wikipedia <ref>{{Cite pmid|19453251}}</ref> Nephropedia Template TP ( {{tp|p=19453251|t=The posttranslational processing of prelamin A and disease |pdf=|usr=|}} Twit Text The posttranslational processing of prelamin A and disease http://www.kidney.de/pget.php?&tw=1&pmid=19453251 DeepDyve Pubget Overpricing

lüll The posttranslational processing of prelamin A and disease Davies BS; Fong LG; Yang SH; Coffinier C; Young SG Annu Rev Genomics Hum Genet 2009[]; 10 (ä): 153-74 Human geneticists have shown that some progeroid syndromes are caused by mutations that interfere with the conversion of farnesyl-prelamin A to mature lamin A. For example, Hutchinson-Gilford progeria syndrome is caused by LMNA mutations that lead to the accumulation of a farnesylated version of prelamin A. In this review, we discuss the posttranslational modifications of prelamin A and their relevance to the pathogenesis and treatment of progeroid syndromes. |*Protein Processing, Post-Translational[MESH] |Animals[MESH] |Disease Models, Animal[MESH] |Enzyme Inhibitors/therapeutic use[MESH] |Farnesyltranstransferase/antagonists & inhibitors[MESH] |Humans[MESH] |Infant, Newborn[MESH] |Lamin Type A[MESH] |Nuclear Proteins/genetics/*metabolism[MESH] |Progeria/drug therapy/genetics/*metabolism[MESH] |Protein Precursors/genetics/*metabolism[MESH]

*{{pmid19453251}}
*<b>[http://www.kidney.de/mlpefetch.php?search=19453251 The posttranslational processing of prelamin A and disease ]</b> Annu Rev Genomics Hum Genet 2009; 10(ä) ; 153-74 Davies BS; Fong LG; Yang SH; Coffinier C; Young SG

    *19453251*

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{{recpmid|pmid=19453251|ti=The posttranslational processing of prelamin A and disease |au=Davies BS; Fong LG; Yang SH; Coffinier C; Young SG|so=Annu Rev Genomics Hum Genet 2009; 10 (ä): 153-74|ab=Human geneticists have shown that some progeroid syndromes are caused by mutations that interfere with the conversion of farnesyl-prelamin A to mature lamin A. For example, Hutchinson-Gilford progeria syndrome is caused by LMNA mutations that lead to the accumulation of a farnesylated version of prelamin A. In this review, we discuss the posttranslational modifications of prelamin A and their relevance to the pathogenesis and treatment of progeroid syndromes.}}
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{{BibRecord | Autor = Davies BS; Fong LG; Yang SH; Coffinier C; Young SG | Titel = The posttranslational processing of prelamin A and disease | Band = 10 | Nummer = ä | Jahr = 2009 | Monat = | Sprache = eng | DOI = | Seite = 153-74 | PMID = 19453251 | Typ= {{{Typ|}}} | Kommentar = {{{Kommentar|}}} | format = {{{format|}}} | record = {{{record|}}} }}

Annu Rev Genomics Hum Genet