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Translocation of proteins through the Sec61 and SecYEG channels Mandon EC; Trueman SF; Gilmore RCurr Opin Cell Biol 2009[Aug]; 21 (4): 501-7The Sec61 and SecYEG translocation channels mediate the selective transport of proteins across the endoplasmic reticulum and bacterial inner membrane, respectively. These channels are also responsible for the integration of membrane proteins. To accomplish these two critical events in protein expression, the transport channels undergo conformational changes to permit the export of lumenal domains and the integration of transmembrane spans. Novel insight into how these channels open during protein translocation has been provided by a combination of the analysis of new channel structures, biochemical characterization of translocation intermediates, molecular dynamics simulations, and in vivo and in vitro analysis of structure-based Sec61 and SecY mutants.|Cell Membrane/metabolism[MESH]|Endoplasmic Reticulum/metabolism[MESH]|Escherichia coli Proteins/*chemistry[MESH]|Escherichia coli/metabolism[MESH]|Lipid Bilayers/chemistry[MESH]|Membrane Proteins/*chemistry[MESH]|Methanococcus/metabolism[MESH]|Models, Biological[MESH]|Molecular Conformation[MESH]|Mutation[MESH]|Protein Conformation[MESH]|Protein Structure, Secondary[MESH]|Protein Structure, Tertiary[MESH]|Protein Transport[MESH]|SEC Translocation Channels[MESH]|Thermus/metabolism[MESH] |