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lüll New insights into the regulation of human B-cell differentiation Schmidlin H; Diehl SA; Blom BTrends Immunol 2009[Jun]; 30 (6): 277-85B lymphocytes provide the cellular basis of the humoral immune response. All stages of this process, from B-cell activation to formation of germinal centers and differentiation into memory B cells or plasma cells, are influenced by extrinsic signals and controlled by transcriptional regulation. Compared to naive B cells, memory B cells display a distinct expression profile, which allows for their rapid secondary responses. Indisputably, many B-cell malignancies result from aberrations in the circuitry controlling B-cell function, particularly during the germinal centre (GC) reaction. Here, we review new insights into memory B-cell subtypes, recent literature on transcription factors regulating human B-cell differentiation and further evidence for B-cell lymphomagenesis emanating from errors during GC cell reactions.|Animals[MESH]|Antibody Formation[MESH]|B-Lymphocyte Subsets/*immunology/metabolism/pathology[MESH]|B-Lymphocytes/*immunology/metabolism/pathology[MESH]|Cell Differentiation[MESH]|Cell Transformation, Neoplastic[MESH]|Chromosome Aberrations[MESH]|Gene Expression Regulation/immunology[MESH]|Germinal Center/*immunology/metabolism[MESH]|Humans[MESH]|Immunologic Memory[MESH]|Lymphoma, B-Cell/genetics/*immunology/pathology[MESH]|Mice[MESH]|Transcription Factors/*immunology[MESH] |