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Self-termination/anergic mechanisms in human basophils and mast cells MacGlashan DW JrInt Arch Allergy Immunol 2009[]; 150 (2): 109-21All cellular reactions include feedback loops, both positive and negative. Following all receptor-mediated stimulation there are events that activate the cell response and events that dampen the receptor response back to resting conditions. IgE-mediated activation of mast cells and basophils necessarily includes a variety of signaling events that serve to terminate the activation processes. Some of these negative feedback loops are active even in resting cells and likely serve to establish a set point for the cell's response to IgE-mediated stimulation. But many negative feedback loops become active only after the cell is stimulated. By and large, it will be these processes that will be discussed in this review.|Animals[MESH]|Basophils/*immunology/metabolism[MESH]|Cell Degranulation/immunology[MESH]|Clonal Anergy/*immunology[MESH]|Down-Regulation/immunology[MESH]|Feedback, Physiological/*immunology[MESH]|Humans[MESH]|Immunoglobulin E/immunology[MESH]|Mast Cells/*immunology/metabolism[MESH]|Signal Transduction/immunology[MESH] |
