Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Review of tenecteplase (TNKase) in the treatment of acute myocardial infarction Melandri G; Vagnarelli F; Calabrese D; Semprini F; Nanni S; Branzi AVasc Health Risk Manag 2009[]; 5 (1): 249-56TNKase is a genetically engineered variant of the alteplase molecule. Three different mutations result in an increase of the plasma half-life, of the resistance to plasminogen-activator inhibitor 1 and of the thrombolytic potency against platelet-rich thrombi. Among available agents in clinical practice, TNKase is the most fibrin-specific molecule and can be delivered as a single bolus intravenous injection. Several large-scale clinical trials have enrolled more than 27,000 patients with acute myocardial infarction, making the use of this drug truly evidence-based. TNKase is equivalent to front-loaded alteplase in terms of mortality and is the only bolus thrombolytic drug for which this equivalence has been formally demonstrated. TNKase appears more potent than alteplase when symptoms duration lasts more than 4 hours. Also, TNKase significantly reduces the rate of major bleeds and the need for blood transfusions. The efficacy of TNKase may be further improved by enoxaparin substitution for unfractionated heparin, provided that enoxaparin dose adjustment is made for patients more than 75 years old. Hitherto, the small available randomized studies and international clinical registries suggest that pre-hospital TNKase is as effective as primary angioplasty, thus laying the foundations for a new fibrinolytic, TNKase-based strategy as the backbone of reperfusion in acute myocardial infarction.|*Thrombolytic Therapy[MESH]|Angioplasty, Balloon, Coronary[MESH]|Blood Transfusion[MESH]|Drug Administration Schedule[MESH]|Drug Therapy, Combination[MESH]|Emergency Medical Services[MESH]|Fibrinolytic Agents/administration & dosage/adverse effects/*therapeutic use[MESH]|Hemorrhage/chemically induced/prevention & control[MESH]|Humans[MESH]|Injections, Intravenous[MESH]|Myocardial Infarction/*drug therapy[MESH]|Tenecteplase[MESH]|Tissue Plasminogen Activator/administration & dosage/adverse effects/*therapeutic use[MESH]|Treatment Outcome[MESH] |
