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Inducible cAMP early repressor (ICER) and brain functions Borlikova G; Endo SMol Neurobiol 2009[Aug]; 40 (1): 73-86The inducible cAMP early repressor (ICER) is an endogenous repressor of cAMP-responsive element (CRE)-mediated gene transcription and belongs to the CRE-binding protein (CREB)/CRE modulator (CREM)/activating transcription factor 1 (ATF-1) gene family. ICER plays an important role in regulating the neuroendocrine system and the circadian rhythm. Other aspects of ICER function have recently attracted heightened attention. Being a natural inducible CREB antagonist, and more broadly, an inducible repressor of CRE-mediated gene transcription, ICER regulates long-lasting plastic changes that occur in the brain in response to incoming stimulation. This review will bring together data on ICER and its functions in the brain, with a special emphasis on recent findings highlighting the involvement of ICER in the regulation of long-term plasticity underlying learning and memory.|Animals[MESH]|Brain/*physiology[MESH]|Cyclic AMP Response Element Modulator/*physiology[MESH]|Cyclic AMP Response Element-Binding Protein/metabolism[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Learning/physiology[MESH]|Memory/physiology[MESH]|Neuronal Plasticity[MESH] |
