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lüll The function of non-coding RNAs in genomic imprinting Koerner MV; Pauler FM; Huang R; Barlow DPDevelopment 2009[Jun]; 136 (11): 1771-83Non-coding RNAs (ncRNAs) that regulate gene expression in cis or in trans are a shared feature of prokaryotic and eukaryotic genomes. In mammals, cis-acting functions are associated with macro ncRNAs, which can be several hundred thousand nucleotides long. Imprinted ncRNAs are well-studied macro ncRNAs that have cis-regulatory effects on multiple flanking genes. Recent advances indicate that they employ different downstream mechanisms to regulate gene expression in embryonic and placental tissues. A better understanding of these downstream mechanisms will help to improve our general understanding of the function of ncRNAs throughout the genome.|Animals[MESH]|DNA Methylation/physiology[MESH]|Embryo, Mammalian/metabolism[MESH]|Female[MESH]|Genomic Imprinting/*physiology[MESH]|Histones/metabolism[MESH]|Mice[MESH]|Placenta/metabolism[MESH]|Pregnancy[MESH]|RNA, Untranslated/*physiology[MESH] |