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lüll Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes Sasai N; Defossez PAInt J Dev Biol 2009[]; 53 (2-3): 323-34DNA methylation is an epigenetically inherited chemical modification that is associated with transcriptional silencing and is essential for mammalian development. The DNA methylation signal is read out by methyl-CpG binding proteins (MBPs) that specifically bind to methylated DNA. Three structurally divergent families of MBPs have been identified so far: the MBD family, the SRA family and a family of proteins with Zinc fingers. In this review, we describe how the distinct families of methyl-CpG binding proteins have evolved, how they each recognize and maintain the DNA methylation mark, and finally how they turn this mark into biological effect.|*DNA Methylation[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Binding Sites/genetics[MESH]|DNA-Binding Proteins/genetics/*metabolism[MESH]|Eukaryotic Cells/*metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Molecular Sequence Data[MESH]|Sequence Homology, Amino Acid[MESH] |