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lüll The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus Cancro MP; D'Cruz DP; Khamashta MAJ Clin Invest 2009[May]; 119 (5): 1066-73SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE.|Animals[MESH]|Autoantibodies/immunology[MESH]|B-Cell Activating Factor/*physiology[MESH]|B-Lymphocytes/cytology/physiology[MESH]|Clinical Trials as Topic[MESH]|Humans[MESH]|Lupus Erythematosus, Systemic/immunology/*metabolism/therapy[MESH]|Models, Biological[MESH]|Self Tolerance/physiology[MESH] |