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Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy Strongin AYBiochim Biophys Acta 2010[Jan]; 1803 (1): 133-41This manuscript provides an overview of the dynamic interactions which play an important role in regulating cancer cell functions. We describe and discuss, primarily, those interactions which involve membrane type-1 matrix metalloproteinase (MT1-MMP), its physiological inhibitor tissue inhibitor of metalloproteinases-2 (TIMP-2), furin-like proprotein convertases and the low density lipoprotein-related protein 1 (LRP1) signaling scavenger receptor. The interaction among these cellular proteins controls the efficiency of the activation of MT1-MMP and the unorthodox intracellular signaling which is generated by the catalytically inert complex of MT1-MMP with TIMP-2 and which plays a potentially important role in the migration of cancer cells. Our in-depth understanding of these cellular mechanisms may provide the key to solving the puzzling TIMP-2 paradox. This unsolved paradox arises from the fact that TIMP-2 is a powerful inhibitor of MMPs including MT1-MMP, but at the same time high levels of TIMP-2 positively correlate with an unfavorable prognosis in cancer patients. Solving the TIMP-2 paradox may lead to solving a similar PAI-1 paradox and produce a clearer understanding of the biochemical mechanisms which control the functionality of the urokinase-type plasminogen activator*urokinase receptor*plasminogen activator inhibitor type-1 (uPAR*uPA*PAI-1) system in cancer.|*Protein Processing, Post-Translational[MESH]|Animals[MESH]|Humans[MESH]|Low Density Lipoprotein Receptor-Related Protein-1/metabolism[MESH]|Matrix Metalloproteinase 14/chemistry/*metabolism[MESH]|Neoplasms/*enzymology/pathology[MESH]|Proprotein Convertases/metabolism[MESH]|Tissue Inhibitor of Metalloproteinase-2/metabolism[MESH] |
