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lüll Minor sarcoplasmic reticulum membrane components that modulate excitation-contraction coupling in striated muscles Treves S; Vukcevic M; Maj M; Thurnheer R; Mosca B; Zorzato FJ Physiol 2009[Jul]; 587 (Pt 13): 3071-9In striated muscle, activation of contraction is initiated by membrane depolarisation caused by an action potential, which triggers the release of Ca(2+) stored in the sarcoplasmic reticulum by a process called excitation-contraction coupling. Excitation-contraction coupling occurs via a highly sophisticated supramolecular signalling complex at the junction between the sarcoplasmic reticulum and the transverse tubules. It is generally accepted that the core components of the excitation-contraction coupling machinery are the dihydropyridine receptors, ryanodine receptors and calsequestrin, which serve as voltage sensor, Ca(2+) release channel, and Ca(2+) storage protein, respectively. Nevertheless, a number of additional proteins have been shown to be essential both for the structural formation of the machinery involved in excitation-contraction coupling and for its fine tuning. In this review we discuss the functional role of minor sarcoplasmic reticulum protein components. The definition of their roles in excitation-contraction coupling is important in order to understand how mutations in genes involved in Ca(2+) signalling cause neuromuscular disorders.|Animals[MESH]|Calcium Signaling/genetics/physiology[MESH]|Humans[MESH]|Models, Biological[MESH]|Muscle Contraction/genetics/*physiology[MESH]|Muscle Proteins/genetics/physiology[MESH]|Muscle, Skeletal/*physiology[MESH]|Sarcoplasmic Reticulum/*physiology[MESH] |