Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll ADAM8: a new therapeutic target for asthma Knolle MD; Owen CAExpert Opin Ther Targets 2009[May]; 13 (5): 523-40BACKGROUND: A proteinase with a disintegrin and a metalloproteinase domain-8 (ADAM8) has been linked to asthma. OBJECTIVE: To explore whether ADAM8 is a therapeutic target for asthma. METHODS: We reviewed literature on ADAM8's function and expression and activities in lungs of humans and mice with allergic airway inflammation (AAI). We used these data to generate hypotheses about the contributions of ADAM8 to asthma pathogenesis. CONCLUSIONS: ADAM8 levels are increased in airway epithelium and airway inflammatory cells in mice with AAI and human asthma patients. Data from murine models of AAI indicate that ADAM8 dampens airway inflammation. It is not clear whether ADAM8 contributes directly to structural remodeling in asthmatic airways. Additional studies are required to validate ADAM8 as a therapeutic target for asthma.|*Drug Delivery Systems[MESH]|ADAM Proteins/*antagonists & inhibitors/chemistry/deficiency/physiology[MESH]|Animals[MESH]|Anti-Asthmatic Agents/*pharmacology/therapeutic use[MESH]|Antigens, CD[MESH]|Asthma/*drug therapy/enzymology/immunology/pathology[MESH]|Child[MESH]|Cytokines/metabolism[MESH]|Drug Evaluation, Preclinical[MESH]|Epithelial Cells/enzymology[MESH]|Extracellular Matrix Proteins/metabolism[MESH]|Fibrosis[MESH]|Humans[MESH]|Leukocytes/enzymology[MESH]|Lung/enzymology/pathology[MESH]|Membrane Proteins/*antagonists & inhibitors/chemistry/deficiency/physiology[MESH]|Mice[MESH]|Mice, Inbred C57BL[MESH]|Mice, Knockout[MESH]|Mice, Transgenic[MESH]|Protease Inhibitors/*pharmacology/therapeutic use[MESH]|Protein Structure, Tertiary[MESH]|Pulmonary Eosinophilia/drug therapy/enzymology/etiology[MESH]|Receptors, Cell Surface/metabolism[MESH] |