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lüll Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs Balagopal V; Parker RCurr Opin Cell Biol 2009[Jun]; 21 (3): 403-8The control of translation and mRNA degradation plays a key role in the regulation of eukaryotic gene expression. In the cytosol, mRNAs engaged in translation are distributed throughout the cytosol, while translationally inactive mRNAs can accumulate in P bodies, in complex with mRNA degradation and translation repression machinery, or in stress granules, which appear to be mRNAs stalled in translation initiation. Here we discuss how these different granules suggest a dynamic model for the metabolism of cytoplasmic mRNAs wherein they cycle between different mRNP states with different functional properties and subcellular locations.|Cytoplasmic Granules/*metabolism[MESH]|Eukaryotic Cells/*metabolism[MESH]|Humans[MESH]|Polyribosomes/*metabolism[MESH]|Protein Biosynthesis[MESH]|RNA Caps/*metabolism[MESH]|RNA Stability[MESH]|RNA, Messenger/*metabolism[MESH]|Ribonucleoproteins/metabolism[MESH] |