Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Immunoregulatory functions of mTOR inhibition Thomson AW; Turnquist HR; Raimondi GNat Rev Immunol 2009[May]; 9 (5): 324-37The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of growth factor-induced T cell proliferation. However, it is now evident that the serine/threonine protein kinase mammalian target of rapamycin (mTOR) has an important role in the modulation of both innate and adaptive immune responses. mTOR regulates diverse functions of professional antigen-presenting cells, such as dendritic cells (DCs), and has important roles in the activation of effector T cells and the function and proliferation of regulatory T cells. In this Review, we discuss our current understanding of the mTOR pathway and the consequences of mTOR inhibition, both in DCs and T cells, including new data on the regulation of forkhead box P3 expression.|Animals[MESH]|Antigen-Presenting Cells/immunology[MESH]|Humans[MESH]|Immune System Phenomena/drug effects/*immunology[MESH]|Immunosuppressive Agents/pharmacology[MESH]|Protein Kinases/*immunology/*metabolism[MESH]|Signal Transduction/immunology[MESH]|T-Lymphocytes, Regulatory/immunology[MESH]|TOR Serine-Threonine Kinases[MESH] |