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lüll Development and validation of a protein-based signature for the detection of ovarian cancer Kim K; Visintin I; Alvero AB; Mor GClin Lab Med 2009[Mar]; 29 (1): 47-55To overcome the significant mortality associated with ovarian cancer, a highly sensitive and specific screening test is urgently needed. CA-125 testing is used to monitor response to chemotherapy, detect recurrence, and detect late stage ovarian cancer. However, CA-125 testing, alone or in combination with ultrasonography, has not been adequate for early detection of ovarian cancer. This article discusses the authors' recent report of a novel multiplex assay that uses a panel of six serum biomarkers: leptin, prolactin, osteopontin, insulin-like growth factor II (IGF-II), macrophage inhibitory factor (MIF), and CA-125. The combination of these six proteins yielded 95.3% sensitivity and 99.4% specificity. The application of this test in the clinical context and the most appropriate population, which could benefit from the test, are discussed.|*Biomarkers, Tumor/blood/urine[MESH]|Data Interpretation, Statistical[MESH]|Enzyme-Linked Immunosorbent Assay[MESH]|Female[MESH]|Humans[MESH]|Ovarian Neoplasms/*diagnosis[MESH]|Protein Array Analysis[MESH]|Proteomics/*methods[MESH]|Reproducibility of Results[MESH] |