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lüll Barrier immunity and IL-17 Marks BR; Craft JSemin Immunol 2009[Jun]; 21 (3): 164-71CD4+ T(H)17 cells display a featured role in barrier immunity. This effector population of T cells is important for clearance of microorganisms but can also promote autoimmunity at barrier sites. Recent work has indicated that these effector cells share a pathway with CD4+ regulatory T cells (T(R) cells) that also have a critical function in barrier protection and immune regulation. The development and function of T(H)17 cells, and their relationship with T(R) cells are discussed.|Animals[MESH]|Autoimmune Diseases/immunology[MESH]|CD4-Positive T-Lymphocytes/immunology/*metabolism/pathology[MESH]|Cell Differentiation[MESH]|Gastrointestinal Tract/*immunology/pathology[MESH]|Humans[MESH]|Immunity, Cellular[MESH]|Immunity, Mucosal[MESH]|Infections/immunology[MESH]|Interleukin-17/chemistry/*immunology/*metabolism[MESH]|Lung/*immunology/pathology[MESH]|Signal Transduction[MESH]|Skin/*immunology/pathology[MESH]|T-Lymphocytes, Regulatory/immunology[MESH]|Transcriptional Activation[MESH] |