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lüll A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme Malynn BA; Ma AJ Exp Med 2009[May]; 206 (5): 977-80Many B cell cancers are characterized in part by the dysregulation of the NF-kappaB signaling pathway. A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-kappaB inhibitor A20, in Hodgkin lymphomas and primary mediastinal lymphomas. These data reveal the role of A20 as a tumor suppressor protein.|Animals[MESH]|Autoimmunity[MESH]|B-Lymphocytes/immunology[MESH]|DNA-Binding Proteins[MESH]|Female[MESH]|Hodgkin Disease/*genetics[MESH]|Humans[MESH]|Immunity, Innate[MESH]|Intracellular Signaling Peptides and Proteins/deficiency/*genetics[MESH]|Lymphocytes/immunology[MESH]|Lymphoma, B-Cell/genetics/immunology[MESH]|Lymphoma/*genetics[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Mutation[MESH]|NF-kappa B/physiology[MESH]|Neoplasms/*genetics[MESH]|Nuclear Proteins/deficiency/*genetics[MESH]|Ovarian Neoplasms/genetics/immunology[MESH]|Tumor Necrosis Factor alpha-Induced Protein 3[MESH]|Tumor Necrosis Factor-alpha/genetics[MESH]|Ubiquitin-Protein Ligases/genetics[MESH] |