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lüll Balance of Th1 and Th17 effector and peripheral regulatory T cells Lohr J; Knoechel B; Caretto D; Abbas AKMicrobes Infect 2009[Apr]; 11 (5): 589-93Transfer of antigen-specific T cells into antigen-expressing lymphopenic recipients leads to the sequential generation of Th1 and Th17 effector and protective CD25(+)FoxP3(+) regulatory cells in the periphery with surprisingly different kinetics. Such an experimental model is potentially valuable for defining the stimuli that regulate lineage decision and plasticity of various T cell effectors and peripheral regulatory T cells. Our studies have shown that IL-17 production occurs rapidly and declines within the first week with the appearance of IFN-gamma producing T cells. Regulatory T cells appear during the recovery phase of the disease. The factors that mediate this complex differentiation originating from a starting naive T cell population remain to be defined.|Cell Differentiation[MESH]|Cell Proliferation[MESH]|Humans[MESH]|Interleukin-17/immunology[MESH]|Lymphocyte Subsets/*immunology[MESH]|T-Lymphocytes, Helper-Inducer/cytology/*immunology[MESH]|T-Lymphocytes, Regulatory/cytology/*immunology[MESH]|Th1 Cells/cytology/*immunology[MESH] |