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lüll Cardiolipin membrane domains in prokaryotes and eukaryotes Mileykovskaya E; Dowhan WBiochim Biophys Acta 2009[Oct]; 1788 (10): 2084-91Cardiolipin (CL) plays a key role in dynamic organization of bacterial and mitochondrial membranes. CL forms membrane domains in bacterial cells, and these domains appear to participate in binding and functional regulation of multi-protein complexes involved in diverse cellular functions including cell division, energy metabolism, and membrane transport. Visualization of CL domains in bacterial cells by the fluorescent dye 10-N-nonyl acridine orange is critically reviewed. Possible mechanisms proposed for CL dynamic localization in bacterial cells are discussed. In the mitochondrial membrane CL is involved in organization of multi-subunit oxidative phosphorylation complexes and in their association into higher order supercomplexes. Evidence suggesting a possible role for CL in concert with ATP synthase oligomers in establishing mitochondrial cristae morphology is presented. Hypotheses on CL-dependent dynamic re-organization of the respiratory chain in response to changes in metabolic states and CL dynamic re-localization in mitochondria during the apoptotic response are briefly addressed.|Animals[MESH]|Cardiolipins/*metabolism[MESH]|Cell Membrane/*metabolism[MESH]|Eukaryotic Cells/*metabolism[MESH]|Humans[MESH]|Prokaryotic Cells/*metabolism[MESH] |