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Emerging concepts in the pathogenesis of epilepsy and epileptogenesis Dichter MAArch Neurol 2009[Apr]; 66 (4): 443-7Recent studies of the problem of ictogenesis, or the ways that seizures develop in an already hyperexcitable brain, are leading to paradigm-shifting concepts that may lead to exciting new therapies for seizures. Research on the equally important area of epileptogenesis, or the ways that a normal brain becomes epileptic, is also expanding, but comparable research into translation of laboratory findings into successful clinical interventions for those at high risk needs to be developed.|*Electroencephalography/drug effects[MESH]|Anticonvulsants/therapeutic use[MESH]|Brain Damage, Chronic/physiopathology[MESH]|Brain/drug effects/pathology/*physiopathology[MESH]|Epilepsies, Partial/pathology/*physiopathology/prevention & control[MESH]|Hippocampus/drug effects/pathology/physiopathology[MESH]|Humans[MESH]|Neocortex/drug effects/pathology/physiopathology[MESH]|Neural Inhibition/physiology[MESH]|Risk Factors[MESH]|Sclerosis[MESH] |
