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Comparison of the rates of joint arthroplasty in patients with severe factor VIII and IX deficiency: an index of different clinical severity of the 2 coagulation disorders Tagariello G; Iorio A; Santagostino E; Morfini M; Bisson R; Innocenti M; Mancuso ME; Mazzucconi MG; Pasta GL; Radossi P; Rodorigo G; Santoro C; Sartori R; Scaraggi A; Solimeno LP; Mannucci PMBlood 2009[Jul]; 114 (4): 779-84Data from the Italian Hemophilia Centres were collected to perform a retrospective survey of joint arthroplasty in patients with severe hemophilia. Twenty-nine of 49 hemophilia centers reported that 328 of the 347 operations were carried out in 253 patients with severe hemophilia A (HA) and 19 in 15 patients with severe hemophilia B (HB). When results were normalized to the whole Italian hemophilia population (1770 severe HA and 319 severe HB), patients with HA had a 3-fold higher risk of undergoing joint arthroplasty (odds ratio [OR], 3.38; 95% confidence interval [CI], 1.97-5.77; P < .001). These results were confirmed after adjustment for age, HIV, hepatitis C virus (HCV), and inhibitor in a Cox regression model (HR, 2.65; 95% CI, 1.62-4.33; P < .001). The survival analysis of time to joint arthroplasty in the subset of patients with severe HA was not affected by the severity of factor VIII (FVIII) gene mutations. A systematic review of literature articles reporting joint arthroplasties in HA and HB showed that the proportion of HA patients who had undergone arthroplasties was higher than that of HB patients, in agreement with the findings in our Italian cohort. These data suggest that the 2 inherited coagulation disorders have a different severity of clinical phenotype.|*Severity of Illness Index[MESH]|Adolescent[MESH]|Adult[MESH]|Algorithms[MESH]|Arthroplasty/*statistics & numerical data[MESH]|Blood Coagulation Disorders/classification/complications/epidemiology/surgery[MESH]|Child[MESH]|Cohort Studies[MESH]|Hemophilia A/complications/epidemiology/*surgery[MESH]|Hemophilia B/complications/epidemiology/*surgery[MESH]|Humans[MESH]|Italy/epidemiology[MESH]|Joint Diseases/complications/*epidemiology/etiology/*surgery[MESH]|Middle Aged[MESH]|Retrospective Studies[MESH]|Risk Factors[MESH]|Young Adult[MESH] |
