suck pdf from google scholar
unlimited free pdf from europmc19356714    free
PDF from PMC    free
html from PMC    free
PDF vom PMID19356714  :  Publisher
PDF vom PMID19356714 :   free
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text


  • DeepDyve
  • Pubget Overpricing


  • lüll
  • Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
  • Purushotham A; Schug TT; Xu Q; Surapureddi S; Guo X; Li X
  • Cell Metab 2009[Apr]; 9 (4): 327-38
  • Hepatic metabolic derangements are key components in the development of fatty liver, insulin resistance, and atherosclerosis. SIRT1, a NAD+-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient availability. Here we demonstrate that hepatic SIRT1 regulates lipid homeostasis by positively regulating peroxisome proliferators-activated receptor alpha (PPARalpha), a nuclear receptor that mediates the adaptive response to fasting and starvation. Hepatocyte-specific deletion of SIRT1 impairs PPARalpha signaling and decreases fatty acid beta-oxidation, whereas overexpression of SIRT1 induces the expression of PPARalpha targets. SIRT1 interacts with PPARalpha and is required to activate PPARalpha coactivator PGC-1alpha. When challenged with a high-fat diet, liver-specific SIRT1 knockout mice develop hepatic steatosis, hepatic inflammation, and endoplasmic reticulum stress. Taken together, our data indicate that SIRT1 plays a vital role in the regulation of hepatic lipid homeostasis and that pharmacological activation of SIRT1 may be important for the prevention of obesity-associated metabolic diseases.
  • |*Gene Deletion[MESH]
  • |Animals[MESH]
  • |Dietary Fats/administration & dosage/pharmacology[MESH]
  • |Endoplasmic Reticulum/drug effects/pathology[MESH]
  • |Fatty Acids/*metabolism[MESH]
  • |Fatty Liver/*complications/*enzymology[MESH]
  • |Feeding Behavior/drug effects[MESH]
  • |Hepatocytes/drug effects/*enzymology[MESH]
  • |Homeostasis/drug effects[MESH]
  • |Inflammation/*complications/enzymology[MESH]
  • |Ligands[MESH]
  • |Lipid Metabolism/drug effects[MESH]
  • |Mice[MESH]
  • |Organ Specificity/drug effects[MESH]
  • |Oxidation-Reduction/drug effects[MESH]
  • |PPAR alpha/metabolism[MESH]
  • |Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha[MESH]
  • |Protein Binding/drug effects[MESH]
  • |Signal Transduction/drug effects[MESH]
  • |Sirtuin 1[MESH]
  • |Sirtuins/*genetics/metabolism[MESH]
  • |Trans-Activators/metabolism[MESH]
  • |Transcription Factors[MESH]
  • |Transcriptional Activation/drug effects[MESH]





  • *{{pmid19356714}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=19356714 Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation ]</b> Cell Metab 2009; 9(4) ; 327-38 Purushotham A; Schug TT; Xu Q; Surapureddi S; Guo X; Li X

        *19356714*

    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren

    Cell Metab

    327 4.9 2009