Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Alternative Abeta immunotherapy approaches for Alzheimer s disease Town TCNS Neurol Disord Drug Targets 2009[Apr]; 8 (2): 114-27In a seminal report in 1999, Schenk and colleagues demonstrated that vaccination of a mouse model of Alzheimer's disease (AD) with amyloid-beta(1-42) peptide (Abeta(1-42)) and adjuvant resulted in striking mitigation of AD-like pathology - giving rise to the field of AD immunotherapy. Later studies confirmed this result in other mouse models of AD and additionally showed cognitive improvement after Abeta vaccination. Based on these results, early developmental clinical trials ensued to immunize AD patients with Abeta(1-42) plus adjuvant (so-called "active" Abeta immunotherapy; trade name AN-1792; Elan Pharmaceuticals, Dublin, Ireland). However, the phase IIa trial was halted after 6 % of patients developed aseptic meningoencephalitis. Despite occurrence of this adverse event, many individuals demonstrated high serum antibody titres to Abeta and histological evidence of clearance of the hallmark AD pathology, beta-amyloid plaques. While raising justifiable safety concerns, these important results nonetheless demonstrated the feasibility of the active Abeta immunotherapy approach. This review focuses on alternative approaches to active Abeta vaccination that are currently in various stages of development - from pre-clinical studies in animal models to current clinical trials. Specifically, the focus is on those strategies that target inflammatory and immune aspects of AD, and can therefore be classified as immunotherapeutic in a broad sense.|Alzheimer Disease/*drug therapy/immunology/physiopathology[MESH]|Alzheimer Vaccines/adverse effects/*pharmacology[MESH]|Amyloid beta-Peptides/adverse effects/*antagonists & inhibitors/immunology/metabolism/pharmacology[MESH]|Animals[MESH]|Clinical Trials as Topic/trends[MESH]|Disease Models, Animal[MESH]|Drug Evaluation, Preclinical/trends[MESH]|Humans[MESH]|Immunotherapy, Active/*methods/*trends[MESH]|Meningitis, Aseptic/chemically induced/immunology[MESH]|Mice[MESH]|Peptide Fragments/adverse effects/immunology/pharmacology[MESH]|Plaque, Amyloid/drug effects/immunology/pathology[MESH] |