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Settling the thymus: immigration requirements Cyster JGJ Exp Med 2009[Apr]; 206 (4): 731-4Thymus settling by precursor cells is essential for the production of T cells, yet the immigration requirements are poorly defined. P-selectin and CC chemokine receptor-9 (CCR9) are involved, and settling is favored when existing residents have moved on. A new study strengthens the correlation between niche emptying and the induction of thymic P-selectin and CCR9 ligand, and provides evidence for feedback from the periphery to thymic P-selectin expression via sphingosine-1-phosphate.|Chemokine CCL26[MESH]|Chemokines, CC/immunology[MESH]|Humans[MESH]|Models, Immunological[MESH]|P-Selectin/physiology[MESH]|Receptors, CCR/immunology[MESH]|Receptors, Chemokine/immunology[MESH]|T-Lymphocytes/immunology[MESH]|Thymus Gland/immunology/*physiology[MESH] |
