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  • Settling the thymus: immigration requirements
  • Cyster JG
  • J Exp Med 2009[Apr]; 206 (4): 731-4
  • Thymus settling by precursor cells is essential for the production of T cells, yet the immigration requirements are poorly defined. P-selectin and CC chemokine receptor-9 (CCR9) are involved, and settling is favored when existing residents have moved on. A new study strengthens the correlation between niche emptying and the induction of thymic P-selectin and CCR9 ligand, and provides evidence for feedback from the periphery to thymic P-selectin expression via sphingosine-1-phosphate.
  • |Chemokine CCL26[MESH]
  • |Chemokines, CC/immunology[MESH]
  • |Humans[MESH]
  • |Models, Immunological[MESH]
  • |P-Selectin/physiology[MESH]
  • |Receptors, CCR/immunology[MESH]
  • |Receptors, Chemokine/immunology[MESH]
  • |T-Lymphocytes/immunology[MESH]
  • |Thymus Gland/immunology/*physiology[MESH]

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    *<b>[ Settling the thymus: immigration requirements ]</b> J Exp Med 2009; 206(4) ; 731-4 Cyster JG


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    J Exp Med

    731 4.206 2009