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Creation of a registry for human embryonic stem cells carrying an inherited defect: joint collaboration between ESHRE and hESCreg Sermon KD; Simon C; Braude P; Viville S; Borstlap J; Veiga AHum Reprod 2009[Jul]; 24 (7): 1556-60Human embryonic stem cells (hESCs), derived from human blastocysts, hold a great promise for regenerative medicine, drug development and basic research in developmental biology. Moreover, hESC lines that carry a clinically relevant inherited defect, monogenic or chromosomal, present an important tool for research into the pathophysiology of these diseases. The hESC registry (hESCreg) was started up in 2007 in order to register all stem cell lines derived in Europe (www.hescreg.eu). Because of the special nature of the hESC lines that carry an inherited disease, they are of particular interest to researchers outside the assisted reproductive technologies or stem cell fields, for instance, those involved in regenerative medicine and in medical and human genetics. To reach these researchers, and to better disseminate the information on the cell lines, a concerted action of the hESCreg together with ESHRE's Special Interest Groups in Reproductive Genetics and Stem Cells was initiated. This mini-review is a first report that will be followed by yearly reports of new lines, not unlike the reports from the Preimplantation Genetic Diagnosis Consortium or the European IVF Monitoring.|Cell Line[MESH]|Chromosome Aberrations[MESH]|Embryonic Stem Cells/*cytology/*pathology[MESH]|Female[MESH]|Genetic Diseases, Inborn/genetics[MESH]|Humans[MESH]|Karyotyping[MESH]|Male[MESH]|Mutation[MESH]|Registries/standards[MESH]|Reproductive Techniques, Assisted/instrumentation[MESH] |
