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Intravenous immunoglobulins (IVIg) in the treatment of autoimmune diseases Kaveri SV; Dietrich G; Hurez V; Kazatchkine MDClin Exp Immunol 1991[Nov]; 86 (2): 192-8Intravenous immunoglobulin (IVIg) therapy is increasingly used in autoimmune diseases. Although its efficacy has only been established in a few specific antibody-mediated autoimmune conditions, accumulating evidence on the regulatory role of circulating immunoglobulins in the selection of peripheral B cell repertoires makes it an attractive potential therapeutic option to clinical immunologists. This overview briefly discusses the current use of IVIg in human autoimmune diseases with a particular emphasis on the possible mechanisms by which IVIg could suppress pathological autoimmune responses.|Antigenic Modulation[MESH]|Autoimmune Diseases/*therapy[MESH]|Humans[MESH]|Immunoglobulin Fc Fragments/immunology[MESH]|Immunoglobulin Variable Region/physiology[MESH]|Immunoglobulins, Intravenous/*therapeutic use[MESH]|Immunotherapy[MESH] |
