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lüll Mechanisms of endothelial dysfunction in obstructive sleep apnea Atkeson A; Jelic SVasc Health Risk Manag 2008[]; 4 (6): 1327-35Endothelial activation and inflammation are important mediators of accelerated atherogenesis and consequent increased cardiovascular morbidity in obstructive sleep apnea (OSA). Repetitive episodes of hypoxia/reoxygenation associated with transient cessation of breathing during sleep in OSA resemble ischemia/reperfusion injury and may be the main culprit underlying endothelial dysfunction in OSA. Additional factors such as repetitive arousals resulting in sleep fragmentation and deprivation and individual genetic susceptibility to vascular manifestations of OSA contribute to impaired endothelial function in OSA. The present review focuses on possible mechanisms that underlie endothelial activation and inflammation in OSA.|Animals[MESH]|Cardiovascular Diseases/*etiology/genetics/metabolism/physiopathology[MESH]|Endothelium, Vascular/metabolism/*physiopathology[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Hypoxia/physiopathology[MESH]|Inflammation Mediators/metabolism[MESH]|Inflammation/complications/genetics/metabolism/*physiopathology[MESH]|Nitric Oxide/metabolism[MESH]|Oxidative Stress[MESH]|Oxygen/metabolism[MESH]|Risk Factors[MESH]|Sleep Apnea, Obstructive/complications/genetics/metabolism/*physiopathology[MESH]|Sleep Deprivation/physiopathology[MESH] |