Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
l�ll
Long-acting nifedipine in the management of the hypertensive patient Snider ME; Nuzum DS; Veverka AVasc Health Risk Manag 2008[]; 4 (6): 1249-57Hypertension is a global condition affecting billions worldwide. It is a significant contributor to cardiovascular events, cardiac death and kidney disease. A number of medication classes exist to aid healthcare providers and their patients in controlling hypertension. Nifedipine, a dihydropyridine calcium channel blocker, was once one of the most widely used medications for hypertension, but safety and tolerability concerns along with the introduction of new classes of antihypertensive medications and an increasing pool of data showing mortality benefit of other classes caused nifedipine to fall out of favor. More recently, long-acting formulations were developed and made available to clinicians. These newer formulations were designed to address many of the concerns raised by earlier formulations of nifedipine. Numerous clinical trials have been conducted comparing long-acting nifedipine to many of the more commonly prescribed antihypertensive medications. This review will address the pharmacology, pharmacokinetics and the available clinical trial data on long-acting nifedipine and summarize its role in the management of hypertension.|Antihypertensive Agents/adverse effects/pharmacokinetics/*therapeutic use[MESH]|Blood Pressure/drug effects[MESH]|Calcium Channel Blockers/adverse effects/pharmacokinetics/*therapeutic use[MESH]|Clinical Trials as Topic[MESH]|Delayed-Action Preparations[MESH]|Drug Chronotherapy[MESH]|Humans[MESH]|Hypertension/*drug therapy/physiopathology[MESH]|Nifedipine/adverse effects/pharmacokinetics/*therapeutic use[MESH]|Treatment Outcome[MESH] |