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lüll Signaling networks associated with BCR-ABL-dependent transformation Hazlehurst LA; Bewry NN; Nair RR; Pinilla-Ibarz JCancer Control 2009[Apr]; 16 (2): 100-7BACKGROUND: The fusion protein BCR-ABL results in constitutive tyrosine kinase activity. It also affects downstream targets as well as the subcellular location of the normally tightly regulated Abl tyrosine kinase. METHODS: The authors review the current knowledge concerning the signaling networks associated with BCR-ABL-dependent transformation. RESULTS: Although BCR-ABL is considered a single genetic change, the dysregulated tyrosine kinase activates a network of signals that contributes to cytokine-independent growth, resistance to apoptosis, and genetic instability. CONCLUSIONS: The effectiveness of BCR-ABL-dependent transformation of hematopoietic stem cells is due not to a single pathway but rather to the culmination of a network of signaling pathways.|Animals[MESH]|Cell Transformation, Neoplastic/*genetics/metabolism[MESH]|Fusion Proteins, bcr-abl[MESH]|Humans[MESH]|Protein-Tyrosine Kinases/metabolism[MESH]|Signal Transduction/*physiology[MESH] |