Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Neuroprotective and cardioprotective conopeptides: an emerging class of drug leads Twede VD; Miljanich G; Olivera BM; Bulaj GCurr Opin Drug Discov Devel 2009[Mar]; 12 (2): 231-9The peptides in the venoms of predatory marine snails belonging to the genus Conus ('cone snails') have well-established therapeutic applications for the treatment of pain and epilepsy. This review discusses the neuroprotective and cardioprotective potential of four families of Conus peptides (conopeptides), including omega-conotoxins that target voltage-gated Ca2+ channels, conantokins that target NMDA receptors, mu-conotoxins that target voltage-gated Na+ channels, and kappa- and kappaM-conotoxins that target K+ channels. The diversity of Conus peptides that have already been shown to exhibit neuroprotective/cardioprotective activity suggests that marine snail venoms are a potentially rich source of drug leads with diverse mechanisms.|*Drug Discovery[MESH]|Animals[MESH]|Calcium Channel Blockers/pharmacology[MESH]|Cardiovascular Agents/chemistry/isolation & purification/*pharmacology[MESH]|Conotoxins/chemistry/isolation & purification/*pharmacology[MESH]|Excitatory Amino Acid Antagonists/pharmacology[MESH]|Humans[MESH]|Neuroprotective Agents/chemistry/isolation & purification/*pharmacology[MESH]|Potassium Channel Blockers/pharmacology[MESH]|Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors[MESH]|Sodium Channel Blockers/pharmacology[MESH]|Structure-Activity Relationship[MESH]|omega-Conotoxins/pharmacology[MESH] |