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MET pathway as a therapeutic target Kim ES; Salgia RJ Thorac Oncol 2009[Apr]; 4 (4): 444-7Dysregulation of mesenchymal-epithelial transition factor receptor tyrosine kinase pathway leads to cell proliferation, protection from apoptosis, angiogenesis, invasion, and metastasis. It can be dysregulated through overexpression, constitutive activation, gene amplification, ligand-dependent activation or mutation. New drugs targeting various mesenchymal-epithelial transition factor pathways are being investigated with promising results.|Animals[MESH]|Humans[MESH]|Neoplasms/*drug therapy/metabolism[MESH]|Phosphorylation[MESH]|Proto-Oncogene Proteins c-met[MESH]|Proto-Oncogene Proteins/*antagonists & inhibitors/chemistry/physiology[MESH]|Receptors, Growth Factor/*antagonists & inhibitors/chemistry/physiology[MESH]|Signal Transduction/drug effects[MESH] |
