Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Regulatory T cells: key players in tolerance and autoimmunity Chatila TAEndocrinol Metab Clin North Am 2009[Jun]; 38 (2): 265-72, viiCD4 + CD25 + regulatory T (TR) lymphocytes are essential to the maintenance of immunologic tolerance in the host. The discovery of Foxp3 as a transcription factor essential to the differentiation of TR ushered in detailed studies of the molecular mechanisms of TR cell development, peripheral homeostasis, and effector functions. In humans, loss of function mutations in genes that regulate T-cell development and function have been associated with TR cell deficiency or dysfunction and syndromes of autoimmunity and immune dysregulation. Augmentation of TR cells by immunotherapy and pharmacologic agents is a promising strategy for the treatment of allergic and autoimmune diseases.|Animals[MESH]|Autoimmune Diseases/*immunology/therapy[MESH]|Autoimmunity/*immunology[MESH]|Humans[MESH]|Immune Tolerance/*immunology[MESH]|T-Lymphocytes, Regulatory/*immunology[MESH] |