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Harnessing nature s toolbox: regulatory elements for synthetic biology Boyle PM; Silver PAJ R Soc Interface 2009[Aug]; 6 Suppl 4 (Suppl 4): S535-46Synthetic biologists seek to engineer complex biological systems composed of modular elements. Achieving higher complexity in engineered biological organisms will require manipulating numerous systems of biological regulation: transcription; RNA interactions; protein signalling; and metabolic fluxes, among others. Exploiting the natural modularity at each level of biological regulation will promote the development of standardized tools for designing biological systems.|Animals[MESH]|Biotechnology/methods[MESH]|Computational Biology/methods[MESH]|Genetic Engineering/*methods[MESH]|Humans[MESH]|Models, Biological[MESH]|Nanotechnology[MESH]|Nucleic Acid Conformation[MESH]|Protein Engineering/methods[MESH]|Proteins/chemistry[MESH]|RNA/chemistry[MESH]|Signal Processing, Computer-Assisted[MESH]|Systems Biology/*methods[MESH]|Transcription, Genetic[MESH] |
