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lüll Sendai viral vector mediated angiopoietin-1 gene transfer for experimental ischemic limb disease Huang J; Inoue M; Hasegawa M; Tomihara K; Tanaka T; Chen J; Hamada HAngiogenesis 2009[]; 12 (3): 243-9Sendai virus vector is emerging as a promising vector for gene therapy, and angiopoietin-1 (Ang-1) has been reported to improve the blood flow recovery in the ischemic limb or heart. In this study, we constructed a human Ang-1-expressing Sendai viral vector (SeVhAng-1) and injected it into the ischemic limb of rats. We found that SeVhAng-1 improved the blood flow recovery and increased the capillary density of the ischemic limb, compared with the controls. We also found that SeVhAng-1 increased p-Akt during the early period of limb ischemia, and decreased apoptosis in ischemic limb. It suggests that SeVhAng-1 may serve as a potential therapeutic tool in ischemic limb disease.|*Genetic Vectors/administration & dosage/genetics/physiology[MESH]|Angiopoietin-1/*administration & dosage/genetics[MESH]|Animals[MESH]|Constriction, Pathologic/genetics/pathology/therapy[MESH]|Disease Models, Animal[MESH]|Gene Transfer Techniques[MESH]|Genetic Therapy[MESH]|Humans[MESH]|Iliac Artery/pathology[MESH]|Injections, Intramuscular[MESH]|Ischemia/genetics/pathology/*therapy[MESH]|Lower Extremity/*blood supply/pathology[MESH]|Male[MESH]|Peripheral Vascular Diseases/genetics/pathology/*therapy[MESH]|Rats[MESH]|Rats, Inbred Lew[MESH]|Sendai virus/*genetics/physiology[MESH] |