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lüll Thymic maturation determines gammadelta T cell function, but not their antigen specificities Jensen KD; Chien YHCurr Opin Immunol 2009[Apr]; 21 (2): 140-5gammadelta T cells contribute uniquely to host immune defense, but how they do so remains unclear. Recent work suggests that thymic selection does little to constrain gammadelta T cell antigen specificities, but instead determines their effector fate. When triggered through the T cell receptor, ligand-experienced cells make IFNgamma, whereas ligand-naive gammadelta T cells produce IL-17, a major initiator of inflammation. These advances warrant a fresh look at how gammadelta T cells may function in the immune system.|Animals[MESH]|Cell Differentiation/*immunology[MESH]|Gene Rearrangement, T-Lymphocyte[MESH]|Humans[MESH]|Interferon-gamma/metabolism[MESH]|Interleukin-17/metabolism[MESH]|Models, Immunological[MESH]|Receptors, Antigen, T-Cell, gamma-delta/genetics/*immunology[MESH]|T-Lymphocytes/cytology/*immunology/metabolism[MESH]|Thymus Gland/cytology/*immunology/metabolism[MESH] |