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lüll The role of TNF superfamily members in T-cell function and diseases Croft MNat Rev Immunol 2009[Apr]; 9 (4): 271-85Interactions that occur between several tumour necrosis factor (TNF)-TNF receptors that are expressed by T cells and various other immune and non-immune cell types are central to T-cell function. In this Review, I discuss the biology of four different ligand-receptor interactions - OX40 ligand and OX40, 4-1BB ligand and 4-1BB, CD70 and CD27, and TL1A and death receptor 3 - and their potential to be exploited for therapeutic benefit. Manipulating these interactions can be effective for treating diseases in which T cells have an important role, including inflammatory conditions, autoimmunity and cancer. Here, I explore how blocking or inducing the signalling pathways that are triggered by these different interactions can be an effective way to modulate immune responses.|*Autoimmune Diseases/drug therapy/immunology[MESH]|*Inflammation/drug therapy/immunology[MESH]|*Neoplasms/drug therapy/immunology[MESH]|Animals[MESH]|Humans[MESH]|Models, Biological[MESH]|Receptors, Tumor Necrosis Factor/agonists/antagonists & inhibitors/physiology[MESH]|Signal Transduction/drug effects/physiology[MESH]|T-Lymphocytes/*immunology/*physiology[MESH]|Tumor Necrosis Factor Inhibitors[MESH]|Tumor Necrosis Factors/agonists/*physiology[MESH] |