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lüll Small RNA molecules in the regulation of spermatogenesis He Z; Kokkinaki M; Pant D; Gallicano GI; Dym MReproduction 2009[Jun]; 137 (6): 901-11Small RNA molecules (small RNAs), including small interfering RNAs (siRNAs), microRNAs (miRNAs), and piwi-interacting RNAs (piRNAs), have recently emerged as important regulators of gene expression at the post-transcriptional or translation level. Significant progress has recently been made utilizing small RNAs in elucidating the molecular mechanisms regulating spermatogenesis. Spermatogenesis is a complex process that involves the division and eventual differentiation of spermatogonial stem cells into mature spermatozoa. The process of spermatogenesis is composed of several phases: mitotic proliferation of spermatogonia to produce spermatocytes; two meiotic divisions of spermatocytes to generate haploid round spermatids; and spermiogenesis, the final phase that involves the maturation of early-round spermatids into elongated mature spermatids. A number of miRNAs are expressed abundantly in male germ cells throughout spermatogenesis, while piRNAs are only present in pachytene spermatocytes and round spermatids. In this review, we first address the synthesis, mechanisms of action, and functions of siRNA, miRNA, and piRNA, and then we focus on the recent advancements in defining the small RNAs in the regulation of spermatogenesis. Concerns pertaining to the use of siRNAs in exploring spermatogenesis mechanisms and open questions in miRNAs and piRNAs in this field are highlighted. The potential applications of small RNAs to male contraception and treatment for male infertility and testicular cancer are also discussed.|*Gene Expression Regulation, Developmental[MESH]|Animals[MESH]|Contraception[MESH]|Genetic Therapy[MESH]|Humans[MESH]|Infertility, Male/genetics/therapy[MESH]|Male[MESH]|MicroRNAs/*metabolism/therapeutic use[MESH]|RNA, Small Interfering/*metabolism/therapeutic use[MESH]|Spermatogenesis/*genetics[MESH]|Spermatozoa/*metabolism[MESH]|Testicular Neoplasms/genetics/therapy[MESH] |