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lüll Vasopressin-independent mechanisms in controlling water homeostasis Cheng CY; Chu JY; Chow BKJ Mol Endocrinol 2009[Sep]; 43 (3): 81-92The maintenance of body water homeostasis depends on the balance between water intake and water excretion. In the kidney, vasopressin (Vp) is a critical regulator of water homeostasis by controlling the insertion of aquaporin 2 (AQP2) onto the apical membrane of the collecting duct principal cells in the short term and regulating the gene expression of AQP2 in the long term. A growing body of evidence from both in vitro and in vivo studies demonstrated that both secretin and oxytocin are involved as Vp-independent mechanisms regulating the renal water reabsorption process, including the translocation and expression of AQP2. This review focuses on how these two hormones are potentially involved as Vp-independent mechanisms in controlling water homeostasis.|*Homeostasis[MESH]|Animals[MESH]|Aquaporins/metabolism[MESH]|Humans[MESH]|Oxytocin/metabolism[MESH]|Secretin/metabolism[MESH]|Vasopressins/metabolism[MESH]|Water/*metabolism[MESH] |