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lüll Shedding light on the intricate puzzle of ghrelin s effects on appetite regulation Kola B; Korbonits MJ Endocrinol 2009[Aug]; 202 (2): 191-8Ghrelin, a hormone primarily produced by the stomach, has a wide range of metabolic and non-metabolic effects. It also stimulates food intake through activation of various hypothalamic and brain stem neurons. A series of recent studies have explored the intracellular mechanisms of the appetite-inducing effect of ghrelin in the hypothalamus, shedding light on the intricate mechanisms of appetite regulation. AMP-activated protein kinase (AMPK) is a key metabolic enzyme involved in appetite regulation. Calmodulin kinase kinase 2 (CaMKK2) has been identified as an upstream kinase of AMPK and a key mediator in the effect of ghrelin on AMPK activity. The fatty acid pathway, hypothalamic mitochondrial respiration, and uncoupling protein 2 have been outlined as downstream targets of AMPK and mediators of ghrelin's appetite stimulating effect. This short overview summarises the present data in this field.|Animals[MESH]|Appetite Regulation/*physiology[MESH]|Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism[MESH]|Cannabinoids/metabolism/pharmacology[MESH]|Drug Interactions[MESH]|Fatty Acids/metabolism[MESH]|Ghrelin/metabolism/*physiology[MESH]|Humans[MESH]|Ion Channels/metabolism[MESH]|Mitochondrial Proteins/metabolism[MESH]|Uncoupling Protein 2[MESH] |