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Targeting protein serine/threonine phosphatases for drug development McConnell JL; Wadzinski BEMol Pharmacol 2009[Jun]; 75 (6): 1249-61With the recent clinical success of drugs targeting protein kinase activity, drug discovery efforts are focusing on the role of reversible protein phosphorylation in disease states. The activity of protein phosphatases, enzymes that oppose protein kinases, can also be manipulated to alter cellular signaling for therapeutic benefits. In this review, we present protein serine/threonine phosphatases as viable therapeutic targets, discussing past successes, current challenges, and future strategies for modulating phosphatase activity.|*Drug Discovery[MESH]|Animals[MESH]|Antineoplastic Agents/pharmacology[MESH]|Catalytic Domain[MESH]|Enzyme Activation[MESH]|Humans[MESH]|Immunosuppressive Agents/pharmacology[MESH]|Multiprotein Complexes/antagonists & inhibitors[MESH]|Phosphoprotein Phosphatases/antagonists & inhibitors/*physiology[MESH]|Phosphorylation[MESH]|Protein Tyrosine Phosphatases/antagonists & inhibitors/*physiology[MESH] |
