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lüll The LDL receptor Goldstein JL; Brown MSArterioscler Thromb Vasc Biol 2009[Apr]; 29 (4): 431-8In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.|*Signal Transduction/genetics[MESH]|Animals[MESH]|Cholesterol/blood/history/*metabolism[MESH]|Endocytosis[MESH]|Feedback, Physiological[MESH]|History, 20th Century[MESH]|History, 21st Century[MESH]|Humans[MESH]|Hydroxymethylglutaryl CoA Reductases/metabolism[MESH]|Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use[MESH]|Lipoproteins, LDL/blood/history/*metabolism[MESH]|Myocardial Infarction/genetics/history/*metabolism/prevention & control[MESH]|Protein Transport[MESH]|Receptors, LDL/genetics/history/*metabolism[MESH] |