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lüll Biochemical signaling pathways for memory T cell recall Farber DLSemin Immunol 2009[Apr]; 21 (2): 84-91Memory T cells exhibit low activation thresholds and rapid effector responses following antigen stimulation, contrasting naive T cells with high activation thresholds and no effector responses. Signaling mechanisms for the distinct properties of naive and memory T cells remain poorly understood. Here, I will discuss new results on signal transduction in naive and memory T cells that suggest proximal control of activation threshold and a distinct biochemical pathway to rapid recall. The signaling and transcriptional pathways controlling immediate effector function in memory T cells closely resemble pathways for rapid effector cytokine production in innate immune cells, suggesting memory T cells use innate pathways for efficacious responses.|*Immunologic Memory[MESH]|Animals[MESH]|CD28 Antigens/immunology/metabolism[MESH]|CD4-Positive T-Lymphocytes/immunology/*metabolism[MESH]|Cytokines/metabolism[MESH]|Humans[MESH]|Immunity, Innate[MESH]|Phospholipase C gamma/metabolism[MESH]|Receptors, Antigen, T-Cell/metabolism[MESH]|Signal Transduction/*immunology[MESH]|T-Box Domain Proteins/metabolism[MESH]|T-Lymphocyte Subsets/immunology/*metabolism[MESH]|Transcriptional Activation/immunology[MESH]|ZAP-70 Protein-Tyrosine Kinase/genetics/immunology/*metabolism[MESH]|p38 Mitogen-Activated Protein Kinases/metabolism[MESH] |