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The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches Orchard CH; Pasek M; Brette FExp Physiol 2009[May]; 94 (5): 509-19The sarcolemmal membrane of mammalian cardiac ventricular myocytes is characterized by the presence of invaginations called transverse tubules (t-tubules). Transverse tubules occur at the Z-line as transverse elements with longitudinal extensions. While the existence of t-tubules has been known for some time, recent experimental studies have suggested that their structure and function are more complex than previously believed. There are, however, aspects of t-tubule function that are not currently amenable to experimental investigation, but can be investigated using computational and mathematical approaches. Such studies have helped elucidate further the possible role of t-tubules in cell function. This review summarizes recent experimental and complementary computational studies which highlight the important role of t-tubules in cardiac excitation-contraction coupling.|*Models, Cardiovascular[MESH]|Action Potentials[MESH]|Animals[MESH]|Calcium Signaling[MESH]|Humans[MESH]|Membrane Proteins/metabolism[MESH]|Myocardial Contraction/*physiology[MESH]|Myocytes, Cardiac/*physiology[MESH]|Sarcolemma/physiology[MESH]|Sarcoplasmic Reticulum/metabolism[MESH] |
