Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
l�ll
Cross-regulation of signaling by ITAM-associated receptors Ivashkiv LBNat Immunol 2009[Apr]; 10 (4): 340-7An important function of receptors that signal through immunoreceptor tyrosine-based activation motifs (ITAMs) is to regulate signaling by heterologous receptors. This review describes mechanisms by which ITAM-associated receptors modulate signaling by Toll-like receptors (TLRs), tumor necrosis factor receptor family members and cytokine receptors that use the Jak-STAT signaling pathway, and the biological importance of this signal transduction cross-talk. ITAM-mediated cross-regulation can either augment or dampen signaling by other receptors. Conversely, TLRs and cytokines modulate ITAM-mediated signaling, by means including activation of beta2 integrins that are coupled to the ITAM-containing adaptors DAP12 and FcRgamma. Integration of ITAM signaling into signaling networks through cross-talk with other signal transduction pathways results in tight regulation and fine tuning of cellular responses to various extracellular stimuli and contributes to induction of specific activation and differentiation pathways.|*Amino Acid Motifs[MESH]|Adaptor Proteins, Signal Transducing/immunology[MESH]|Animals[MESH]|CD18 Antigens/immunology/metabolism[MESH]|Humans[MESH]|Immunoglobulin Variable Region/immunology[MESH]|Janus Kinases/immunology/physiology[MESH]|Membrane Proteins/immunology[MESH]|Receptor Cross-Talk/immunology[MESH]|Receptors, Cell Surface/immunology/*physiology[MESH]|Receptors, Cytokine/immunology/physiology[MESH]|Receptors, Immunologic/immunology/physiology[MESH]|Receptors, Tumor Necrosis Factor/immunology/physiology[MESH]|STAT Transcription Factors/immunology/physiology[MESH]|Signal Transduction/*immunology[MESH]|Toll-Like Receptors/immunology/physiology[MESH] |