Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Tie2 is tied at the cell-cell contacts and to extracellular matrix by angiopoietin-1 Fukuhara S; Sako K; Noda K; Nagao K; Miura K; Mochizuki NExp Mol Med 2009[Mar]; 41 (3): 133-9Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor tyrosine kinase. Ang1-Tie2 signal has been proposed to exhibit two opposite roles in the controlling blood vessels. One is vascular stabilization and the other is vascular angiogenesis. There has been no answer to the question as to how Tie2 induces two opposite responses to the same ligand. Our group and Dr. Alitalos group have demonstrated that trans-associated Tie2 at cell-cell contacts and extracellular matrix (ECM)-anchored Tie2 play distinct roles in the endothelial cells. The complex formation depends on the presence or absence of cell-cell adhesion. Here, we review how Ang1-Tie2 signal regulates vascular maintenance and angiogenesis. We further point to the unanswered questions that must be clarified to extend our knowledge of vascular biology and to progress basic knowledge to the treatment of the diseases in which Ang1-Tie2-mediated signal is central.|Angiopoietin-1/*physiology[MESH]|Animals[MESH]|Cell Adhesion/physiology[MESH]|Cell Movement/physiology[MESH]|Endothelial Cells/*physiology[MESH]|Endothelium, Vascular/physiology[MESH]|Extracellular Matrix/*metabolism[MESH]|Humans[MESH]|Neovascularization, Physiologic/physiology[MESH]|Receptor, TIE-2/*physiology[MESH]|Signal Transduction/*physiology[MESH] |