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Carbohydrate recognition by boronolectins, small molecules, and lectins Jin S; Cheng Y; Reid S; Li M; Wang BMed Res Rev 2010[Mar]; 30 (2): 171-257Carbohydrates are known to mediate a large number of biological and pathological events. Small and macromolecules capable of carbohydrate recognition have great potentials as research tools, diagnostics, vectors for targeted delivery of therapeutic and imaging agents, and therapeutic agents. However, this potential is far from being realized. One key issue is the difficulty in the development of "binders" capable of specific recognition of carbohydrates of biological relevance. This review discusses systematically the general approaches that are available in developing carbohydrate sensors and "binders/receptors," and their applications. The focus is on discoveries during the last 5 years.|Animals[MESH]|Antigens, Neoplasm/chemistry[MESH]|Biomarkers, Tumor/chemistry[MESH]|Boronic Acids/*chemistry[MESH]|Carbohydrates/*chemistry[MESH]|Cattle[MESH]|Cell Line, Tumor[MESH]|E-Selectin/chemistry[MESH]|Fluorescent Dyes/chemistry[MESH]|Humans[MESH]|Kinetics[MESH]|Lectins/*chemistry[MESH]|Ligands[MESH]|Mice[MESH]|Protein Binding[MESH] |
